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Contact Info

Skills

Bayesian statistical modelling

Data visualization

iOS, macOS, and watchOS app development

Programming Languages

Main

Joshua Cook

Graduent Student Researcher

As an undergrad, I studied the parasite Toxoplasma gondii, and I currently study cancer genetics using bioinformatics with a specific focus on Bayesian methods. I am looking to once again switch disciplines but continue utilizing and improving my Bayesian statistical analysis skills.

Education

Harvard Medical School

Biomedical and Biological Sciences PhD. program

Boston, MA

present - 2017

Studying cancer genetics with bioinformatics and statistical modeling.

University of California, Irvine

B.S. in Biochemistry and Molecular Biology & B.S. in Chemistry

Irvine, CA

2017 - 2013

Magna Cum Laude with a cumulative GPA of 3.94 and Honors in Biology.

Research Experience

Graduate Research

Harvard Medical School

Boston, MA

present - 2017

  • Studied the tissue- and allele-specific genetic interactions of KRAS in cancer using thousands of human tumor samples.
  • Bayesian hierarchical modeling of CRISPR-Cas9 loss-of-function screens.

Undergraduate Research

Dept. of Molecular Biology and Biochemistry, UCI

Irvine, CA

2017 - 2014

  • Investigated the patterns and mechanisms of dissemination by which Toxoplasma gondii, an obligate, intracellular parasite, infects a human host.

Research Interneship

Saban Research Institute, Los Angeles

Los Angeles, CA

2014

  • Studied the underlying causes of developmental disruptions within the hypothalamus that are characteristic of Prader-Willi syndrome.

Research Interneship

Saban Research Institute, Los Angeles

Los Angeles, CA

2012

  • Researched the role of liver progenitor cells in these two rare, yet deadly, early onset diseases.

Publications

The origins and genetic interactions of KRAS mutations are allele- and tissue-specific

Nat. Commun.

N/A

2021

Joshua H Cook, Giorgio E M Melloni, Doga C Gulhan, Peter J Park, Kevin M Haigis

Tissue-Specific Oncogenic Activity of KRASA146T

Cancer Discov.

N/A

2019

Emily J Poulin, Asim K Bera, Jia Lu, Yi-Jang Lin, Samantha Dale Strasser, Joao A Paulo, Tannie Q Huang, Carolina Morales, Wei Yan, Joshua Cook, Jonathan A Nowak, Douglas K Brubaker, Brian A Joughin, Christian W Johnson, Rebecca A DeStefanis, Phaedra C Ghazi, Sudershan Gondi, Thomas E Wales, Roxana E Iacob, Lana Bogdanova, Jessica J Gierut, Yina Li, John R Engen, Pedro A Perez-Mancera, Benjamin S Braun, Steven P Gygi, Douglas A Lauffenburger, Kenneth D Westover, Kevin M Haigis

Toxoplasma gondii disrupts $$1 integrin signaling and focal adhesion formation during monocyte hypermotility

J. Biol. Chem.

N/A

2018

Joshua H Cook, Norikiyo Ueno, Melissa B Lodoen

Loss of Magel2 impairs the development of hypothalamic Anorexigenic circuits

Hum. Mol. Genet.

N/A

2016

Julien Maillard, Soyoung Park, Sophie Croizier, Charlotte Vanacker, Joshua H Cook, Vincent Prevot, Maithe Tauber, Sebastien G Bouret