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Joshua Cook
Graduent Student Researcher
As an undergrad, I studied the parasite Toxoplasma gondii, and I currently study cancer genetics using bioinformatics with a specific focus on Bayesian methods. I am looking to once again switch disciplines but continue utilizing and improving my Bayesian statistical analysis skills.
Education
Harvard Medical School
Biomedical and Biological Sciences PhD. program
Boston, MA
present - 2017
Studying cancer genetics with bioinformatics and statistical modeling.
University of California, Irvine
B.S. in Biochemistry and Molecular Biology & B.S. in Chemistry
Irvine, CA
2017 - 2013
Magna Cum Laude with a cumulative GPA of 3.94 and Honors in Biology.
Research Experience
Graduate Research
Harvard Medical School
Boston, MA
present - 2017
- Studied the tissue- and allele-specific genetic interactions of KRAS in cancer using thousands of human tumor samples.
- Bayesian hierarchical modeling of CRISPR-Cas9 loss-of-function screens.
Undergraduate Research
Dept. of Molecular Biology and Biochemistry, UCI
Irvine, CA
2017 - 2014
- Investigated the patterns and mechanisms of dissemination by which Toxoplasma gondii, an obligate, intracellular parasite, infects a human host.
Research Interneship
Saban Research Institute, Los Angeles
Los Angeles, CA
2014
- Studied the underlying causes of developmental disruptions within the hypothalamus that are characteristic of Prader-Willi syndrome.
Research Interneship
Saban Research Institute, Los Angeles
Los Angeles, CA
2012
- Researched the role of liver progenitor cells in these two rare, yet deadly, early onset diseases.
Publications
The origins and genetic interactions of KRAS mutations are allele- and tissue-specific
Nat. Commun.
N/A
2021
Joshua H Cook, Giorgio E M Melloni, Doga C Gulhan, Peter J Park, Kevin M Haigis
Tissue-Specific Oncogenic Activity of KRASA146T
Cancer Discov.
N/A
2019
Emily J Poulin, Asim K Bera, Jia Lu, Yi-Jang Lin, Samantha Dale Strasser, Joao A Paulo, Tannie Q Huang, Carolina Morales, Wei Yan, Joshua Cook, Jonathan A Nowak, Douglas K Brubaker, Brian A Joughin, Christian W Johnson, Rebecca A DeStefanis, Phaedra C Ghazi, Sudershan Gondi, Thomas E Wales, Roxana E Iacob, Lana Bogdanova, Jessica J Gierut, Yina Li, John R Engen, Pedro A Perez-Mancera, Benjamin S Braun, Steven P Gygi, Douglas A Lauffenburger, Kenneth D Westover, Kevin M Haigis
Toxoplasma gondii disrupts $$1 integrin signaling and focal adhesion formation during monocyte hypermotility
J. Biol. Chem.
N/A
2018
Joshua H Cook, Norikiyo Ueno, Melissa B Lodoen
Loss of Magel2 impairs the development of hypothalamic Anorexigenic circuits
Hum. Mol. Genet.
N/A
2016
Julien Maillard, Soyoung Park, Sophie Croizier, Charlotte Vanacker, Joshua H Cook, Vincent Prevot, Maithe Tauber, Sebastien G Bouret